Carcinoma in situ of the anus

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Anal Cancer: ESMO-ESSO-ESTRO Clinical Practice Guidelines

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Pathology Outlines - Dysplasia

The anus is an organ that lies at the end of the digestive tract below the rectum. It consists of two sections: the anal canal and the anus or anal verge. The anal canal is a cm long structure that lies between the anal sphincter one of the muscles that controls bowel movements just below the rectum and the anal verge which represents the transition point between the digestive tract and the skin on the outside of the body. Muscles within the anal canal and anus control the passage of stool from the rectum to outside the body. Cancer is when cells grow in an uncontrolled way which can lead to a tumor forming. Anal cancer is a malignant cancerous tumor of either the anal canal or anal verge.
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What Is Anal Cancer?

The treatment of choice is surgical resection with anal mapping. However, this disease often recurs or persists, requiring additional surgery for these patients. This can compromise the anal sphincter leading to leakage. In this case report, we discuss the efficacy of radiation therapy as a modality to treat post-excisional recurrent Bowen's disease, which may prevent sphincter compromise, leading to improved quality of life.
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Anal cancer is a rare tumor with an incidence that has been rising over the last 25 years. The disease was once thought to develop as a result of chronic irritation, but it is now known that this is not the case. Multiple risk factors, including human papillomavirus HPV infection, anoreceptive intercourse, cigarette smoking, and immunosuppression, have been identified.
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