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A spinal cord injury — damage to any part of the spinal cord or nerves at the end of the spinal canal cauda equina — often causes permanent changes in strength, sensation and other body functions below the site of the injury. If you've recently experienced a spinal cord injury, it might seem like every aspect of your life has been affected. You might feel the effects of your injury mentally, emotionally and socially. Many scientists are optimistic that advances in research will someday make the repair of spinal cord injuries possible. Research studies are ongoing around the world.
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Medicinal Chemical Properties of Successful Central Nervous System Drugs

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Over the past decade, we have made considerable progress in establishing diffuse intrinsic pontine glioma DIPG as a disease entity and developing preclinical tools to interrogate potential therapeutics. However, translation to improved clinical outcomes in children with DIPG has not yet been realized. This is in part due to difficulties encountered in delivering active drugs adequately to the tumor site. However, most preclinical evaluations gloss over the fundamental concepts of central nervous system CNS pharmacokinetics and requirements needed to optimize drug delivery and exposure and translate this into efficacious therapy.
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LRP-1-mediated intracellular antibody delivery to the Central Nervous System

E-mail address: tim. Use the link below to share a full-text version of this article with your friends and colleagues. Learn more. To test this hypothesis, this study characterized the impact of common aldehyde fixatives on the MRI properties of a rat brain slice model. Magn Reson Med,
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